A D-Link DNS-320 NAS for home backup (mostly pictures and personal videos) and tarsnap for my VPSs or any local data that I want to backup remotely.
Where I work we have a 'server' computer running windows. I went for backblaze as an online backup option (full disk backup) because it's easy to use, it has a 'sort' of encryption[1] and it's pay-once save all kind of thing, so I don't have to bother all that much. Oh, also we have great upstream speed at the office so problems there...
That said, since my upstream speed at home is limited, the things that I can backup on the cloud are limited.
[1] Backblaze's encryption key is submitted on the browser, via JS. Not the most secure scheme you can find. IMHO if you're not worried about state-level espionage that's fine.