To me, 'nuance' is just a word to describe "the sub-surface stuff that has no immediate and apparent effect within a local system." So, when I say "ignoring the nuance ignores the larger problem", I'm suggesting that there's a large set of problems occurs when you ignore the lon-local effects - ideologically and physically.
It's a complicated problem with many, many components. Nuance is more relevant than you think it is. Think of fractals and weather patterns.
An effect of SF: http://www.chicagotribune.com/news/globalcity/ct-global-city...
Why it happens: https://en.wikipedia.org/wiki/Human_capital_flight