At the risk of being overly pragmatic, note that I said "fast enough" and not "as fast as possible."
My comment was more on the perception that python is unworkably slow in many situations, where I can count the number of times on my hands that I've NEEDED to C-ify some hot paths.
If you're writing a plasma fluid simulation to run on a HHPC cluster, yes, you probably damn well want some straight C/C++. Outside of similarly exceedingly high throughput situations, CPUs are normally more than fast enough, especially if the application in any way brushes up against people and thus falls into "human time" scales, in which case you'd typically be hard pressed to make things slow enough for someone to notice. (Yet somehow we find a way...)
To a sister post re: where python->C speedup can occur, to two birds with one stone, I imagine there's a lot of low hanging fruit, to take one obvious one, anything the compiler can optimize away. Memory read/address optimization, vectorization, potentially better support for branch prediction, I can handwave at more but I am so far from a compilers type that I'd probably make a fool of myself.
