I'm not sure dead code elimination works in that situation. Consider:

  var obj = {
   a: ...
   b: ...
   c: ...
  }

If a, b, and c are functions, there is not necessarily a way to determine at compile time whether they will be used at runtime.

  var prop = webrequest();
  obj[prop]();

In that scenario, a, b, and c cannot be eliminated. But it would be worth testing Google Closure Compiler to see what it does in what scenarios.

I've heard ES6 modules solve this problem, but it seems like dynamic access to an ES6 module might still be possible, which would cause the same problems for DCE. Perhaps no one writes code that way, so it doesn't necessarily matter. But what about eval?

There are lots of tricky corner cases. It seems better to use small atoms than a monolithic package.