The US is very much like 5 to 12 different countries pretending to be one.

Personally, I'd classify the culturally distinct areas as Pacific Coast, Big West, Mormonland, Deep South, Mid-Atlantic, North Mexico, Eastern Megalopolis (Washington DC to Boston), Middle Neutralia, Flori-duh (aka Murica's Glans), and Cajun Country.

Having visited most at least once, and lived in three for at least a year, each are impressive in different ways. It isn't always a positive impression.