Not really, there are tools that can take C header files and spit out bindings. Rust also supports vararg C functions even though Rust itself doesn't support varargs. Writing safe Rust wrappers around these unsafe C bindings can sometimes be tedious, but this isn't worse than using C directly (which is inherently unsafe).

For very extensive C APIs like this (Lua, GTK, etc.) we typically see people create thin, Rust-friendly wrappers to reduce the amount of manual API calls that need to be written out.