For starters: Occupational safety (branches falling down and crushing you on a tire swing), fire safety, bedbugs, noise/loud parties, litter, criminal occupancy, secondary vice (drug dens/prostitution/craigslist orgies/etc). The problem of a bunch of sailors coming into port has been recognized since antiquity. Skeezy/short term motels have a reputation for a reason, and are regulated for even better ones. You yourself may be a perfectly upstanding citizen who just couchsurfs for a weekend to check out a cool area, but others are not.
It's unreasonable to expect neighbors to file daily lawsuits against their neighbors to keep a modicum of peace. It's a known problem and it's perfectly reasonable to preempt it by either requiring a formal lease with a minimum term of a month or more, or requiring more identification/scrutiny of the clients and some formal standards of the rentiers.
Analogously, it's perfectly fine for banks to scrutinize large cash transactions. Some of them are legit, some of them are tied to crime. But you need to look and be sure because it's high-risk activity. If you don't want that level of scrutiny, send a check/transfer/CC payment and your reputation will speak for itself.