1. A knob that can't be configured can't be misconfigured (IIRC Debian had a hole in its default selinux config for years that created a vulnerability selinux-less machines didn't have)
2. (This was more what I meant) the promise that makes people like MACs is that you no longer need a single all-powerful root user to do everything (this bleeds into ACLs and capabilities, too), but keeps running into two icebergs:
2a. Somebody still has to administer those controls, and so can effectively become that all-powerful root, and
2b. The only stuff I actually care about is the actual data that the application being sandboxed can access to begin with.
This gives us the particularly pointless exercise in which somebody who steals my laptop can impersonate me on gmail and social media, empty my bank account, and delete all my github repos, but can't change the laptop's time zone. The system files that I can download for free at any time are protected, but the manuscript for my novel is not.