Developing drugs is not just about taking on big pharma, it's about the risk of causing long-term harm or death to innocent people. There are very good reasons why there is such a strict regulation around new drugs. They only exist to avoid repetitions of what happened in the past. It's easy to be against big pharma, but we shouldn't forget that they improved our lives quite a bit (not associated in any way with a pharma company).

It would be an incredibly tough fight for sure. I guess this can only be won if there's someone with huge resources doing this more for philantrophic reasons than commercial ones.