Here is a 68000 machine with an ISA bus I built in 1987:
http://www.merlintec.com/lsi/merlin2.html
It originally had an Ethernet interface instead of a bus, but since I couldn't get a PC Ethernet board to connect it to I ripped that out and did a simple ISA (actually 8 bit PC bus instead of full ISA) interface. This allowed me to use PC floppy and HD boards as seen in the picture so I could have a "sneakernet" in place of the missing Ethernet.