Fucking hell; they've tripped themselves retarded.
I guess there's no harm in trying.
Ok, so maybe I'd find it easier to believe if it was explained as some kind of wormholes opening up to our senses that allow us to occupy some kind of Avatar from this point in space.
I guess you could have two trippers meet in this space and exchange information. That should be testable.
Here is how it messes with your heart valves: https://en.wikipedia.org/wiki/5-HT2B_receptor
Note that DMT is in the list, along with some similar things that people play with.