Maybe OT, but pilots have a lot of time off between shifts and it's starting to come to light that their depression rates are much higher than anyone is comfortable admitting. This may from a different source though, since flying is very much about precise repetition and less about complex decision making (ADM is hard, but not the same level of mental stress that doctors endure), you eventually realize that you're a very highly trained bus driver.
It's way more complex than that though. The regulations exist because companies were pushing pilots to do more than they could handle, leading to a number of high profile crashes. Yes, the pilots are incentivized to manage fatigue but it's like any other profession, it's easy to get complacent.