Granted there has been some progress but not to the extent promised by M2K.
I haven't really followed nootropics but besides Modafinil (which is not really a smart drag) what smart drugs actually pass a meaningful double blind test?
There are a lot of smart drugs developed by the Russian pharmaceutical industry for neurodegenerative diseases. They are completely ignored in the U.S except by the online nootropics community. A quick Google search will tell you all about it.
