I tend to polyfill older browsers, Array.from is a pretty small one. Sad thing is at a point where it's probably worth it to have 2-3 builds in place... 1 for legacy browsers, one for modern without modules, and one for modules/import/http2 support.
Just haven't taken the time... at least the main app I work on at work doesn't need to support IE11. Latest Edge,, Firefox, Safari and Chrome ... and Chrome is the primary target.