The "true secure" way is not running any untrusted code, not connecting to any untrusted networks, and not accepting or storing any untrusted data.
At that point you can't run a computer. It's just not an answer to say "don't let bad things in" because bad things are always going to get in.
And with side channel exploits getting more and more common, and with them being worse and worse, running any code on your machine is basically giving that code any and all of your data on the machine...
Telling users (even highly technical users) to "never ever run any untrusted code ever, and if you mess up once and run untrusted code you have completely ruined the trust of the whole machine and need to start over from scratch while assuming all of your data has been compromised" is not only infeasible, it's impossible. If this is the case, we have lost the "security" game.
It's easy to say "throwing oo execution away" is an overreaction, but if it's necessary to allow multiple programs to run on one machine without them all having what amounts to full access to one another's information, then it might be necessary. Already we know that we can't use compression with encryption, we can't use any kind of "exit early" with most kinds of encryption. It might just be that OO execution is fundamentally opposed to secure computing. At it's core, it's letting the processor do different things depending on what it can see is coming, it's almost a definition of an oracle! That's always going to be a very dangerous game to play.
It could even just be that CPUs need a "secure computing" mode, or maybe even a secure co-processor that disables all of these optimizations. But at the very least, I think changes are going to be necessary, and a 15% perf reduction might be the least of our worries.
Chrome and FF need "execute JS" to be an explicit per-site permission, similar to the permissions model of native smartphone apps.
Google will never do this because they're an ad company and care more about targeting ads than protecting Chrome users.
I would personally like that, but it's too optimistic to think that the average user would gain much security from it. Most of them will discover that things work fine when they click OK/Accept, and sometimes break when they don't, and so they become conditioned to just click OK/Accept all the time to avoid potential hassle. So in the end it just reduces productivity without increasing security much.
However this wouldn't completely solve the issue (see Google Play Store).