Using LUTs either at the application or OS level to adjust colour information is a big no-no, although that doesn't stop some people from doing it. You simply don't want to change your colour space[1] until you absolutely have to.
The point of calibrating your monitor (which is a hardware + firmware level problem) is to see how your RGB image will look on a colour space restricted piece of hardware (for example in video this is often 12-bit RGB --> Rec709).