Most of what OoO and speculative execution are doing for performance on modern CPUs is hiding L2 and L3 cache latency. On a modern system running common workloads it's pretty unpredictable when you're going to miss L1 as it's dependent on complex dynamic factors. Cell tried replacing automatically managed caches with explicitly managed on chip memory and that proved very difficult to work with for many problems. There's been little investment in technologies to better use software managed caches since then because no other significant CPU design has tried it. It's not a problem LLVM attempts to address to my knowledge.

Other perf problems are fundamental to the way we structure code. C++ performance advantages come in part from very aggressive inlining but OoO is important when inlining is not practical which is still a lot of the time.