I had to relocate an opossum recently and it was disappointing for that reason. Unfortunately it took up residence near my house (20ft away under a shed) and for the meantime it's a risk to a tiny puppy we have. It would not bother me if he made his way back in six months though.
That seems like a good reason for relocation. I would probably relocate any that lived in my yard (if I had a yard at the moment) simply because I wouldn't want my two 60 pound dogs to try and "play" with it.