My only advice would be to stay consistent, find patterns and genralize stuff. I do see the irony of making a framework of my own in the process of doing all that. I just embrace that. Everything is exactly how we want it and we know each line that executes on the machine. Makes development a breeze. There is nothing that react can do that vanilla js can't with reasonably same amount of effort. But stay open-minded. What helped me was that I worked with angular first to see how not to do front end (angular.js). I also regularly check out how react, angular, Vue, etc handle the same problems that I have. That usually gives an inspiration.

In the end it's hard to believe how fast JavaScript can be even on smaller devices.