Absolutely - the very first thing I did was disable every automatic mail setting. It's 100% manual now.
The key data point is that a _reboot_ of the phone, and then doing nothing but making phone calls, results in pretty good battery life for three (sometimes four) days.
But, I'm frequently tempted to click on some apps (zillow, maps, safari) - and then, if I don't reboot the phone, I'm down to 0% within a maximum of 16 hours, regardless of how careful I close all of my apps with the backgrounder tool.
I love my iPhone so much, that this is more interesting than upsetting. But I'd _really_ love to know what, precisely, is pulling the battery down.