There is no need for an anarchist collective. You can just go to a third world country an import the drugs. Or you can start a pharma company. Or you can buy proper equipment and hire experienced people. The only reason for doing it yourself, and go to hacker conferences be applauded by people with no knowledge of the subject whatsoever, is to live a fantasy that can't exist if it is effective. And there is no way to loose because ignorant people will always say you did what you could in the face of Goliath even though anyone who was competent knew what would happen.
It is all fake. Just look at every other diy initiative to date that hasn't affected big companies in the slightest. "Hackers" are still perfectly happy about their "successes" while they make six figure salaries helping the oligopoly. Because there is always a new hacker conference, online forum or meetup you can visit to feel good about yourself by excluding people who know better.
These opinions can only exist in a place where the popularity of ignorance is favored over reason. And you'll deserve each other.
The problem with most libertarian ideas like this is externalities. If you take something made incorrectly and become incredibly sick, society has to either take care of you or let you die- and no one wants to let people just die. So instead, society foots the bill for taking care of you.
I'm not saying these guys aren't fighting a damn good fight. They're in the right, in my mind. But if they start a large enough movement with enough people then someone somewhere is going to eventually cut a corner or make a mistake and get someone killed or made seriously ill. And what then?
There is no reason why Epipens cost $300 other than the fact the FDA has a huge backlog [1] and other regulatory constraints. There are plenty of companies chomping at the bit to deliver that medication for cheaper.
Like you said, this alternative is less than ideal, these hackers weren't driven to this just for fun - it was born out of what they saw as a lack of other options, a necessity (same with their 'customers' who were pushed to the shadier/riskier option). This necessity is generated when the primary market is not delivering value properly/efficiently, creating a demand for it.
The more free the legal market, the more the black market will be far less lucrative. The same applies to drugs and many other markets which artificial controls/limitations.
This all must be factored into the balances of costs measured against the externalities it imposes on society. It's riskier than pure top-down/government intervention but sometimes it's a necessary risk when that option continually fails to reform/change and nothing else pushes the hand of the gov/industry to adapt.
Sure you could blame the black market, but the simpler solution would be to fix the original problem which caused the black market to exist.
[1] http://slatestarcodex.com/2016/08/29/reverse-voxsplaining-dr...