A big problem for the US is that it is a litle off, while most other social/cultural areas are closely connected. For instance, China and Russia might be almost as close allies as the pre-Trump US and Europe. But because Russia and Europe are so close, in fact the business dependencies between both are quite high as well. So a lot of business happens in that exchange, with high values due to the political risks. Since the US lacks such interdependencies with close neighbors it can survive better in a time like WW2 but it is harder in a long peace time like we currently have.