There are ways to take most pressure of your spine, while still allowing you to sanely use a mouse/keyboard (the later has to be split). It's mostly a fitted seat with a semi-fancy headrest, the latter has to be designed to keep your head from rolling to the side. Also you need slightly channeled armrests, which need to be adapted in extend/channel depth depending on how far your hands have to move. If you use a steno keyboard, likely not at all, if you use a graphics tablet, likely much further.
You still might need to move every once in a while though.
