No, in fact it's likely very beneficial. Virtual DOM is meant to avoid the overhead of interacting with the real DOM (reading and writing to the DOM is slow). Being inside a web worker means that you're still interacting through the DOM, just via a web worker now. So the cost of reading and writing to and from the DOM is still present, plus there's the added overhead of communicating with the UI thread. So vdom in this case makes a meaningful difference by allowing the thread to get more work done in a shorter amount of time.

If you, for instance, blew away the whole DOM and re-rendered it (e.g., setting `innerHTML`) on every state change, the cost is going to be far higher than just tweaking the few things that might need tweaking, like on a keypress. If you're not keeping a virtual DOM around, there's no way to know what the diff is between your new and previous state to be able to make those tweaks.