Ask HN: Third party email provider vs. custom email address and spam problem

There are two ways of using email addresses, either use something like abc@gmail.com, abc@fastmail.com or use your own custom domain like me@customdomain.com.

Given that any email address that's given out quickly becomes a target for spammers, does it makes sense to actually give out the custom email address? I assume that the answer is going to be yes. In such situation, what are the precautions that you guys take to reduce the amount of spam you get? What are some of the example places where you give out your custom email address?

My assumption is that having a custom domain gives one the independence of changing providers, and each provider will reduce spam to a different degree.