I have been revisiting buildout recently and I wish there's something that merge ease of use of pipenv with buildout concept. Perhaps something similar to Nix throw in the mix, but more specific to a Python project. I heard that I can do this with Conda, but I never tried.

Being able to define and install external dependencies (e.g. ImageMagick, libsodium, etc.) from a configuration file local to a project is something I missed the most, especially when I'm working on several projects at once.