The crops are designed to withstand Roundup, while weeds are not, so farmers can use Roundup to control weeds with crops that would normally be killed by the herbicide.
Roundup (glyphosate) ready is baby stuff compared to the newer stuff that is resistant to 2,4d/Dicamba. Mostly because the weeds have outsmarted the glyphosate.
Drift from 2,4d will wipe out plants (like your garden, or my vineyard, or like, endangered native plants) many kilometres away.