I'm not sure what the up or downsides would be, but I personally just have all mail sent to *@mydomain.tld forwarded to a single email address. This way I can give each service a unique email address, while preserving the ability to divine whether a particular address has been lost or stolen, by looking at the sent to field.
Well, there's the obvious comfort of having all your mail in one place -- and all the obvious disadvantages that entails, I suppose.