3 out of ~7-8 people I know in the Mission (uncertainty is because of different definitions of "know" and "the Mission" - is Dolores Triangle part of the Mission? Bernal?) have gotten mugged. One was on 16th & Folsom, another around 24th or 25th & Mission walking home to Bernal Heights, a third around 22nd & Van Ness. This is also over a fairly long period of time - over 10 years or so, though the people in question largely don't live in the Mission anymore.
It seems like the East side of the Mission (Folsom & Van Ness) is significantly less safe than the west side (Valencia & Guerrero) - I'll walk down Valencia and feel perfectly safe, while I'm always looking around me between Mission & Folsom.