Maybe not airliner level of safety, but based on the top causes of car accidents, they could probably be reduced by an order of magnitude with relatively inexpensive improvements:
1. better driver training
2. breathalyzer ignition interlocks
3. speed limiters (even more reduced speed at night/rain)
4. traffic light detection/automatic braking
5. enforced following distance
(I'd add "sleep/impaired driver warnings", automatic emergency braking (including pedestrian detection) even though it doesn't quite relate to the top causes of accidents))
Here's the top ten:
1. Distracted Driving
2. Drunk Driving
3. Speeding
4. Reckless Driving
5. Rain
6. Running Red Lights
7. Night Driving
8. Design Defects/Maintenace
9. Tailgating
10. Wrong-Way Driving/ Improper Turns