I programmed C back in my high school years 14+ years ago. Today I am mostly using JS because it is the cash crop of the industry, and it made me quite some money when I was away from electronics business (my main occupation) for a year after getting troubles with Canadian visas.
To me, it feels that there is a very thick wall in between high level languages and something with raw data access like C, C++, and D. You either completely throw out every convenience feature, or go all in on them.
In C, a lot of data access turns into single digit number of load/store or register access instructions. It is easy to see that it is close to impossible to add fancy data access functionality on top of that without going from single cycles to kilocycles.
I was once told "when your try improving a programming language performance, it eventually turns into C"
P.S. on JIT - it is not given that a JIT language be automatically faster than a well written interpreter on a modern CPU. One of early tricks of making fast interpreters was to keep as much of interpreter in cache and data in registers as possible to benefit from more or less linear execution flow of unoptimised code in comparison to unpredictable flow of JIT made executable code. Today, with 16MB caches, I think the benefit of that will be even bigger.