Even after running it for years, Spamassassin never marked a legitimate mail as spam, so i'm pretty sure that if i wasn't too lazy to configure it to move it to a spam folder, it'd work fine. Stuff did pass through it (at a ratio of one every four or so) but i was fine with deleting those.
What i'm trying to say is that from personal experience, i'd be fine with a spam filter that errs on the side of not marking stuff for spam and me deleting whatever goes through manually. Having to see a bit of spam mail is small cost for losing mail i'm actually interested in.
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