It’s odd how that goes. We are never going to subject as many monkeys to coke as people drinking the stuff. So we need to compromise, but rats are not a great model resulting in some false positives. However, presumably some false negatives exist that are silently killing hundreds of thousands of people.
I would like to think that any scientist who dared propose giving to monkeys the equivalent by body mass of the amount of Coca-Cola many humans consume per day would get publicly crucified by an ethics board.
I've never been able to eat an entire orange or an entire mango. But drinking an entire two-liter bottle of Coke over the course of a couple of hours while coding or writing?
We're running a half-assed trial on the general public right now, only without a defined "normal dose", control group, compensation, or informed consent.