Is that really the case though? With flex box and grids it seems like it should be as simple as making sure that your design is based on proportions instead of static values (e.g. "evenly space the three columns across 80% of the page" instead of "Make three columns separated by 10pt with 30 pt before the first column and after the last").
It also seems like it's a whole lot easier to make changes to a wireframe than to fight with CSS rules.