AFAIK, being HTTP, you won't be able to differentiate and/or route it. And it can be done outside the control of the OS or browser (with js embedded in a page, application, etc.) so even if you configure your browser/system, it still will pass through filters unless whole domains are filtered?
Since pihole and dnsmasq are already requiring disabling DoH, I see DoH as the dead of these kinds of adblock systems.
