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0 pointsdoitLP6y ago0 comments

Sure but the list of drugs that cross that barrier is long. Everything from antibiotics to statins.

And even if they didn’t, the body is a tightly interconnected system. Taking an antidepressant to “selectively affect serotonin” in the brain? Whoops, turns out your gut has at least as many serotonin receptors as the brain. Taking a statin to reduce cholesterol (which it does very well but with an NNT > 200 for heart attacks and NNT > 300 for stroke)? Whoops, it causes transient global amnesia and personality changes and diabetes in a lot of people. And 40% of the US Adult population we’re on statins in the mid 2000s.

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xiphias26y ago

I believe you, but I just wanted to read up about where serotonin receptors are expressed in the human body in what amount, but the Wikipedia page on serotonin receptors didn't write about it.

I'm not in the medical field, but try to keep up just a little bit to have some basic knowledge, but it's quite hard as often I see that Wikipedia is many years behind.

At the same time medical articles take a lot of time to read, as they are much less accessable.

sizzle6y ago

Very interesting claims, please share the citations.

doitLPOP6y ago

1) NNT meta analysis (one of a very large body of literature): https://www.thennt.com/nnt/statins-persons-low-risk-cardiova...

2) Best I could find in 2 minutes. Will look for the studies. https://www.scientificamerican.com/article/gut-second-brain/

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