I've also obviously made mistakes and while the mistake spotlight is shining in your face, it feels pretty magnified, especially if you're one who has previously earned significant technical respect. For three years, I led the group in our company responsible for post-morteming every production issue, and reporting to our business leadership in a weekly meeting every issue that cost us more than $2000. In all that time, and in the rest of my two decades in the field, I don't think I've ever sensed a whiff of "you made that mistake because of your extra X chromosome..." (unfamiliar with Leah Culver, but will google now)