Basically, with co-routines you lose the need for all the container types like Mono, Flux, etc. and replace them with simple suspend functions. This makes code a lot more readable, easier to test, and reason about.
Instead of callbacks for errors, you can rely on the normal try/catch. Any uncaught exception causes the co routine and co routine scope to fail and cancel in a controlled way. The Flow API allows you to do reactive style processing. It also handles back pressure and a few other things.
Basically fully reactive code written using this is structurally very similar to the normal blocking version of the code.