Covid vaccine passes phase 1 human trial (opens in new tab)

Would the use of the Adenovirus vector used here foreclose future gene therapies delivered with a similar vector? If so, that could devastate in one go a lot of people’s ability to get specific therapies as they start to come online in the next decade.

Here’s the critical paragraph from results. I think another path forward would be to keep the low/medium dosing but titer for lack of Ad5 antibodies before qualifying a patient for the vaccine.

> Before vaccination, 20 (56%) participants in the low dose group, 19 (53%) participants in the middle dose group, and 16 (44%) participants in the high dose group had a high pre-existing Ad5 neutralising antibody titre (>1:200). Only five (25%) participants of 20 in the low dose group, seven (37%) participants of 19 in the middle dose group, and ten (63%) participants of 16 in the high dose group, who had high pre-existing Ad5 immunity, had at least a four-fold increase in neutralising antibody titre at day 28 post-vaccination (appendix pp 8–10). Multivariable analysis showed that high pre-existing Ad5 neutralising antibody titres compromised the seroconversion of neutralising antibody post-vaccination, regardless of the vaccine doses, and recipients aged 45–60 years seemed to have lower seroconversion of neutralising antibody compared with the younger recipients (appendix p 11). The Ad5 neutralising antibodies were significantly boosted post-vaccination (appendix p 12).

It is generally well-regarded. Its editors have a political position that is occasionally exhibited in the publication of agenda-based content, but for the most part and with all the usual caveats it is trustworthy where scientific papers are concerned.

Yes it is highly rated journal, I have not read the article yet but the headline seems like a fact than an opinion.

See also the PACE trial.

Nope. It sucks that China has a such a stranglehold on pharmaceuticals, but I guarantee you 100% that almost nobody will give a shit where a vaccine is made if it's perceived to be safe and effective. The vaxxers don't care where it's made, and the rest of us will only need to be convinced that it's safe enough given our individual conditions.

I think it's a safe bet that there will be multiple different vaccines. What you get will be determined by availability firstly, and safety profile if necessary. It's really no different from any of the medicines we already use. For example, the vast majority of antibiotics are manufactured in China; have you ever heard of someone turning down antibiotics because they were made in the wrong country?

Phase 1 is intended to exclude the high risk population, and most of today's medications are made in china.

The thought experiment is fascinating.

Say, the United States votes Trump in for a 2nd term. And he goes on a media blitz to convince people to not take the China vaccine.

Meanwhile, the rest of the world takes it. The vaccine is ultimately successful, and Covid-19 is effectively eliminated.

What will happen to the United States? Will the virus continue to ravage the country and the economy? Meanwhile, the rest of the world begins their economic recovery.

Never could I imagine that this idea would even be a probability. But yet, here we are.