I read a boatload of 2 column PDFs on my phone. Liquid Mode has been on PDF Reader on Android for... it feels like a year now? And it's fantastic. Without it I have to constantly pinch and zoom and swipe to the upper right to start a new column, etc.

I hate PDFs, but if I want to read a document I've stored in print fidelity from the 80s on my phone, Liquid is rock solid.