The two main things I notice:
Some websites basically crash the computer on Firefox but run fine on Safari. Mostly JS heavy sites.
The energy usage of Firefox is way higher than Safari, which in turns makes my fans spin a lot harder. Basically some sites will peg the CPU and hit max fan speed, but the same site just sips energy on Safari.
Video streaming is a prime example of this. I can use twitch on Safari and it uses maybe 30% CPU. Twitch on Firefox uses 150% CPU.