My workstation sits about 25ft away from me, in a completely separate room. A thick bundle of cables runs from the desk to the workstation.

I used to use a similar setup. Just need to invest in extension cables, and it can work nicely.

Probably less of a concern, but it also moves the heat output.

A previous comment in this thread mentioned QuietPC [0] in a list of prebuilt companies.

They have some really cool fanless builds, that if you were using a CPU like the AMD 4750g [1], you would have zero noise, and it'd make for a very decent workstation.

[0] https://www.quietpc.com/systems

[1] https://www.quietpc.com/sys-amd-da2-fanless-z2