And sometimes it's great, because you get to focus on the content, and sometimes it's not, because you lose control. It's something that should be optional or configurable. It's great to have shortcuts for the most common commands (like space for pause in youtube), and I guess it would make a lot of sense if video conferencing tools also had such a shortcut for mute/unmute.
But again, give people more control over their UI. There are too many applications that mess this up one way or another.