If you mean that you just want to mute/unmute a zoom session, then also yes - you configure the stream deck to output key press events so you'd program it to output the keyboard shortcuts that you want. Not sure if Zoom has separate mute/unmute shortcuts and if you change settings with the regular keyboard/mouse you might get the display state of the stream deck out of sync with the actual state of the software, that would probably be finicky and/or a lot of work to solve.

I'm still tweaking my setup but using this piece of kit with a good quality webcam, a Blue Yeti mic on an arm, and OBS, being able to control Zoom/MS Teams/Skype in a uniform way, having ultimate control over what part the desktop I share, how I pre-process audio, being able to show my desktop with myself in the corner, ... is already so much better than the clunky default experiences of each of these video conferencing tools. It's like programming with vim - yes I spend an inordinate amount of time 20+ years ago getting proficient with it, but using it just feels like an extension of my brain, like using a Hilti drill hammer vs using a bargain bin Chinese piece of junk.