I'm in the UK, and made my first ever charge back a couple of months back, after Ryanair refused to refund a flight that was cancelled due to corona virus (we'd booked it before the pandemic started). I'd paid with my CC (a UK card; not sure why it would be any different with a US CC?). I forget the exact sum, but it was something like £1,500.
Ryanair completely took the piss - they were very clearly trying to hold on to everyone's money for the duration, and ignored communications or offered ridiculous, short-lived credit notes in lieu of a refund. Several months passed like this.
Eventually I read up on how charge backs worked and called my card provider. They sent a form, and within a couple of weeks, the money was back in my account - the whole process was really straightforward, and I fully recommend using it if a vendor is outright refusing to uphold their side of the bargain.