My laptop is 1366x768 and it feels "wrong" to be zooming-in when screen real estate is already so limited. But once you get over the initial weirdness, you'll just keep doing it. Right now, on my desktop, I have HN at 250% zoom. I can make out 100%, 150% is perfectly readable, but 250% just feels great. Also many sites, including HN, have unlimited or very long paragraph widths so zooming fixes that too.