Hello! I'm the developer of GameLisp :)
You're correct that I've chosen safety and convenience over performance. I might eventually consider integrating the Cranelift code generator to try to achieve LuaJIT-like performance, but it's definitely not on the short-term roadmap.
In practice, I find that GameLisp is more than fast enough to script a busy 2D platformer, as long as you're sensible about using Rust for the more CPU-intensive parts of your game engine.
Incidentally, I'm planning to release GameLisp 0.2 within the next few days - happy to field any other questions while I'm here!