Just not the browser natively....
Most backend frameworks don't need numerous layers of transpilation because they're on an actual OS and arent trying to work around an insane environment like the browser that's full of warts and incompatibilities.
What's the churn on Pandas? It's been around over a decade. And it can probably be reliably counted on to be around a decade more.
It will be surprising if React is around in 5 more years and hasn't been replaced by something else.
Is EmberJS still around? How much longer will webpack be around?
Stability in the browser ecosystem starts with stability in the browser.
I think instead of investing all this energy into browser frameworks we need to be devoting energy into making the browser do what we want it to do natively.
And as web assembly matures that's where I think this is headed.