In my experience, the most common 'don't match the job requirement' issue is mostly about lack of experience (e.g. out of school and applying to senior position).

And in this case I don't really blame them for trying

I've even toyed with the idea of compensating for this by having two sets of job ads -- one with very high requirements, and one with just the bare minimum. Then accept applicants for interview from each based on the applicant's statistical propensity to exaggerate their abilities.