I haven't done anything significant with Mongrel2 yet, so my mental model of its operation is probably somewhat flawed, but I was thinking about my above post for a while yesterday.
It seems like WSGI supports a subset of Mongrel2 features. Any "pure" WSGI app can run fine behind Mongrel2, but Mongrel2 allows much more than the WSGI model. For example, a response in Mongrel2 is just a socket getting written to. Mongrel2 can send a request to server A, and then receive the response from a completely seperate server B. Can WSGI support something like this? As far as I know, someone would need to reimplement a lot of Mongrel2's functionality in Python (which is idiotic) just for WSGI compliance.
Again, I've yet to build anything with Mongrel2 and I haven't read the WSGI PEP in a while, so please correct me if I'm wrong about anything. After thinking about it yesterday, I find the differences between a more traditional WSGI-esque model and something like Mongrel2 to be fascinating.